Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures

Excessive activation of mTOR in microglia impairs CNS homeostasis and causes severe epilepsy. Autophagy constitutes an important part of mTOR signaling. The contribution of microglial autophagy to CNS homeostasis and epilepsy remains to be determined. Here, we report that ATG7KO mice deficient for a...

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Publicat a:eNeuro
Autors principals: Alam, Mahabub Maraj, Zhao, Xiao-Feng, Liao, Yuan, Mathur, Ramkumar, McCallum, Sarah E., Mazurkiewicz, Joseph E., Adamo, Matthew A., Feustel, Paul, Belin, Sophie, Poitelon, Yannick, Zhu, Xinjun Cindy, Huang, Yunfei
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2021
Matèries:
Research Article: New Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7890520/
https://ncbi.nlm.nih.gov/pubmed/33472865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0183-20.2021
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