Induction of autophagy in Cx3cr1(+) mononuclear cells limits IL-23/IL-22 axis-mediated intestinal fibrosis

Intestinal fibrosis is an excessive proliferation of myofibroblasts and deposition of collagen, a condition frequently seen in Crohn’s disease (CD). The mechanism underlying myofibroblast hyper-proliferation in CD needs to be better understood. In this report, we found that mTOR inhibitor rapamycin...

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Bibliografiske detaljer
Udgivet i:Mucosal Immunol
Main Authors: Mathur, Ramkumar, Alam, Mahabub Maraj, Zhao, Xiao-Feng, Liao, Yuan, Shen, Jeffrey, Morgan, Shannon, Huang, Tingting, Lee, HwaJeong, Lee, Edward, Huang, Yunfei, Zhu, Xinjun
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6927046/
https://ncbi.nlm.nih.gov/pubmed/30765845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-019-0146-4
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