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What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?: Rigorous Simian Immunodeficiency Virus Vaccine Trials Can Be Instructive
Simian immunodeficiency virus (SIV) challenge of rhesus macaques provides an invaluable tool to evaluate the clinical prospects of HIV-1 vaccine concepts. However, as with any animal model of human disease, it is crucial to understand the advantages and limitations of this system to maximize the tra...
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| Veröffentlicht in: | Cold Spring Harb Perspect Biol |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5880168/ https://ncbi.nlm.nih.gov/pubmed/28348034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a029504 |
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