Combinatorial Omics Analysis Reveals Perturbed Lysosomal Homeostasis in Collagen VII-deficient Keratinocytes

The extracellular matrix protein collagen VII is part of the microenvironment of stratified epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 lead to the skin disorder dystrophic epidermolysis bullosa (DEB), are linked to skin fragility and progressive inflammat...

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Publicat a:Mol Cell Proteomics
Autors principals: Thriene, Kerstin, Grüning, Björn Andreas, Bornert, Olivier, Erxleben, Anika, Leppert, Juna, Athanasiou, Ioannis, Weber, Ekkehard, Kiritsi, Dimitra, Nyström, Alexander, Reinheckel, Thomas, Backofen, Rolf, Has, Cristina, Bruckner-Tuderman, Leena, Dengjel, Jörn
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880109/
https://ncbi.nlm.nih.gov/pubmed/29326176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA117.000437
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