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Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa

Genetic loss of collagen VII causes recessive dystrophic epidermolysis bullosa (RDEB), a skin fragility disorder that, unexpectedly, manifests also with elevated colonization of commensal bacteria and frequent wound infections. Here, we describe an unprecedented systemic function of collagen VII as...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Nyström, Alexander, Bornert, Olivier, Kühl, Tobias, Gretzmeier, Christine, Thriene, Kerstin, Dengjel, Jörn, Pfister-Wartha, Andrea, Kiritsi, Dimitra, Bruckner-Tuderman, Leena
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789908/
https://ncbi.nlm.nih.gov/pubmed/29305555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1709111115
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