Sustained Dorzolamide Release Prevents Axonal and Retinal Ganglion Cell Loss in a Rat Model of IOP–Glaucoma

PURPOSE: To determine if one injection of a sustained release formulation of dorzolamide in biodegradable microparticles (DPP) reduces retinal ganglion cell (RGC) loss in a rat model of glaucoma. METHODS: We injected either DPP or control microparticles intravitreally in rats. Two days later, unilat...

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Published in:Transl Vis Sci Technol
Main Authors: Pitha, Ian, Kimball, Elizabeth C., Oglesby, Ericka N., Pease, Mary Ellen, Fu, Jie, Schaub, Julie, Kim, Yoo-Chun, Hu, Qi, Hanes, Justin, Quigley, Harry A.
Format: Artigo
Language:Inglês
Published: The Association for Research in Vision and Ophthalmology 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879766/
https://ncbi.nlm.nih.gov/pubmed/29616152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.7.2.13
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