Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

PURPOSE: To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS: We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Quigley, Harry A., Pitha, Ian F., Welsbie, Derek S., Nguyen, Cathy, Steinhart, Matthew R., Nguyen, Thao D., Pease, Mary Ellen, Oglesby, Ericka N., Berlinicke, Cynthia A., Mitchell, Katherine L., Kim, Jessica, Jefferys, Joan J., Kimball, Elizabeth C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624713/
https://ncbi.nlm.nih.gov/pubmed/26505191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141137
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