Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

PURPOSE: To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS: We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone,...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Quigley, Harry A., Pitha, Ian F., Welsbie, Derek S., Nguyen, Cathy, Steinhart, Matthew R., Nguyen, Thao D., Pease, Mary Ellen, Oglesby, Ericka N., Berlinicke, Cynthia A., Mitchell, Katherine L., Kim, Jessica, Jefferys, Joan J., Kimball, Elizabeth C.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624713/
https://ncbi.nlm.nih.gov/pubmed/26505191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141137
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