Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma

PURPOSE: To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS: We produced IOP increase in CD1 mice and performed unilateral optic nerve crush. Mice received oral losartan, spironolactone,...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Quigley, Harry A., Pitha, Ian F., Welsbie, Derek S., Nguyen, Cathy, Steinhart, Matthew R., Nguyen, Thao D., Pease, Mary Ellen, Oglesby, Ericka N., Berlinicke, Cynthia A., Mitchell, Katherine L., Kim, Jessica, Jefferys, Joan J., Kimball, Elizabeth C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4624713/
https://ncbi.nlm.nih.gov/pubmed/26505191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0141137
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