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The effects of age on mitochondria, axonal transport, and axonal degeneration after chronic IOP elevation using a murine ocular explant model

The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant model. We studied 2 transgenic mouse strains, bot...

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Detalhes bibliográficos
Publicado no:Exp Eye Res
Main Authors: Kimball, Elizabeth C., Jefferys, Joan L., Pease, Mary E., Oglesby, Ericka N., Nguyen, Cathy, Schaub, Julie, Pitha, Ian, Quigley, Harry A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5994189/
https://ncbi.nlm.nih.gov/pubmed/29625080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.04.001
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