EL20, A Potent Antiarrhythmic Compound, Selectively Inhibits Calmodulin Deficient Ryanodine Receptor Type 2

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disorder caused by mutations in the cardiac ryanodine receptor (RyR2) that increase diastolic Ca(2+) leak from the sarcoplasmic reticulum (SR). Calmodulin (CaM) dissociation from RyR2 has been associated wi...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: Klipp, Robert C., Li, Na, Wang, Qiongling, Word, Tarah A., Sibrian-Vazquez, Martha, Strongin, Robert M., Wehrens, Xander H.T., Abramson, Jonathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879004/
https://ncbi.nlm.nih.gov/pubmed/29248564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2017.12.017
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