Increasing T‐type calcium channel activity by β‐adrenergic stimulation contributes to β‐adrenergic regulation of heart rates

KEY POINTS: Cav3.1 T‐type Ca(2+) channel current (I(Ca‐T)) contributes to heart rate genesis but is not known to contribute to heart rate regulation by the sympathetic/β‐adrenergic system (SAS). We show that the loss of Cav3.1 makes the beating rates of the heart in vivo and perfused hearts ex vivo,...

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Bibliographic Details
Published in:J Physiol
Main Authors: Li, Yingxin, Zhang, Xiaoxiao, Zhang, Chen, Zhang, Xiaoying, Li, Ying, Qi, Zhao, Szeto, Christopher, Tang, Mingxin, Peng, Yizhi, Molkentin, Jeffery D., Houser, Steven R., Xie, Mingxing, Chen, Xiongwen
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Cardiovascular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878229/
https://ncbi.nlm.nih.gov/pubmed/29274077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274756
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