Calcium Influx through Cav1.2 Is a Proximal Signal for Pathological Cardiomyocyte Hypertrophy

Pathological cardiac hypertrophy (PCH) is associated with the development of arrhythmia and congestive heart failure. While calcium (Ca(2+)) is implicated in hypertrophic signaling pathways, the specific role of Ca(2+) influx through the L-type Ca(2+) channel (I(Ca-L)) has been controversial and is...

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Main Authors: Chen, Xiongwen, Nakayama, Hiroyuki, Zhang, Xiaoying, Ai, Xiaojie, Harris, David M., Tang, Mingxin, Zhang, Hongyu, Szeto, Christopher, Stockbower, Kathryn, Berretta, Remus M., Eckhart, Andrea D., Koch, Walter J., Molkentin, Jeffery D., Houser, Steven R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035763/
https://ncbi.nlm.nih.gov/pubmed/21111744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.11.012
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