Enhanced basal contractility but reduced excitation-contraction coupling efficiency and β-adrenergic reserve of hearts with increased Cav1.2 activity

Cardiac remodeling during heart failure development induces a significant increase in the activity of the L-type Ca(2+) channel (Cav1.2). However, the effects of enhanced Cav1.2 activity on myocyte excitation-contraction (E-C) coupling, cardiac contractility, and its regulation by the β-adrenergic s...

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Main Authors: Tang, Mingxin, Zhang, Xiaoying, Li, Yingxin, Guan, Yinzheng, Ai, Xiaojie, Szeto, Christopher, Nakayama, Hiroyuki, Zhang, Hongyu, Ge, Shuping, Molkentin, Jeffery D., Houser, Steven R., Chen, Xiongwen
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930392/
https://ncbi.nlm.nih.gov/pubmed/20543081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00265.2010
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