Persistent Increases in Ca(2+) Influx through Cav1.2 Shortens Action Potential And Causes Ca(2+) Overload-induced Afterdepolarizations and Arrhythmias

Persistent elevation of Ca(2+) influx due to prolongation of the action potential (AP), chronic activation of the β-adrenergic system and molecular remodeling occurs in stressed and diseased hearts. Increases in Ca(2+) influx are usually linked to prolonged myocyte action potentials and arrhythmias....

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Detalhes bibliográficos
Publicado no:Basic Res Cardiol
Main Authors: Zhang, Xiaoying, Ai, Xiaojie, Nakayama, Hiroyuki, Chen, Biyi, Harris, David M, Tang, Mingxin, Xie, Yuping, Szeto, Christopher, Li, Yingxin, Li, Ying, Zhang, Hongyu, Eckhart, Andrea D., Koch, Walter J., Molkentin, Jeffery D., Chen, Xiongwen
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4876110/
https://ncbi.nlm.nih.gov/pubmed/26611208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-015-0523-4
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