Structure-based discovery of selective positive allosteric modulators of antagonists for the M(2) muscarinic acetylcholine receptor

Subtype-selective antagonists for muscarinic acetylcholine receptors (mAChRs) have long been elusive, owing to the highly conserved orthosteric binding site. However, allosteric sites of these receptors are less conserved, motivating the search for allosteric ligands that modulate agonists or antago...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Korczynska, Magdalena, Clark, Mary J., Valant, Celine, Xu, Jun, Moo, Ee Von, Albold, Sabine, Weiss, Dahlia R., Torosyan, Hayarpi, Huang, Weijiao, Kruse, Andrew C., Lyda, Brent R., May, Lauren T., Baltos, Jo-Anne, Sexton, Patrick M., Kobilka, Brian K., Christopoulos, Arthur, Shoichet, Brian K., Sunahara, Roger K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2018
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877965/
https://ncbi.nlm.nih.gov/pubmed/29453275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1718037115
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