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Accelerated structure-based design of chemically diverse allosteric modulators of a muscarinic G protein-coupled receptor
Design of ligands that provide receptor selectivity has emerged as a new paradigm for drug discovery of G protein-coupled receptors, and may, for certain families of receptors, only be achieved via identification of chemically diverse allosteric modulators. Here, the extracellular vestibule of the M...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5035859/ https://ncbi.nlm.nih.gov/pubmed/27601651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1612353113 |
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