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The Role of Post-Translational Modifications on Prion-Like Aggregation and Liquid-Phase Separation of FUS

Subcellular mislocalization and aggregation of the human FUS protein occurs in neurons of patients with subtypes of amyotrophic lateral sclerosis and frontotemporal dementia. FUS is one of several RNA-binding proteins that can functionally self-associate into distinct liquid-phase droplet structures...

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發表在:Int J Mol Sci
Main Authors: Rhoads, Shannon N., Monahan, Zachary T., Yee, Debra S., Shewmaker, Frank P.
格式: Artigo
語言:Inglês
出版: MDPI 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877747/
https://ncbi.nlm.nih.gov/pubmed/29547565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19030886
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