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Yeast Models of Prion-Like Proteins That Cause Amyotrophic Lateral Sclerosis Reveal Pathogenic Mechanisms

Many proteins involved in the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS) are remarkably similar to proteins that form prions in the yeast Saccharomyces cerevisiae. These ALS-associated proteins are not orthologs of yeast prion proteins, but are similar in having long, intrinsically...

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Bibliografische gegevens
Gepubliceerd in:Front Mol Neurosci
Hoofdauteurs: Monahan, Zachary T., Rhoads, Shannon N., Yee, Debra S., Shewmaker, Frank P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6297178/
https://ncbi.nlm.nih.gov/pubmed/30618605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00453
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