Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

BACKGROUND: Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation can cause exaggerated neuroinflammatory responses and trigger progressive neurodegeneration. Dimethyl fumarate (DMF) is a FDA-appro...

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Vydáno v:J Neuroinflammation
Hlavní autoři: Paraiso, Hallel C., Kuo, Ping-Chang, Curfman, Eric T., Moon, Haley J., Sweazey, Robert D., Yen, Jui-Hung, Chang, Fen-Lei, Yu, I-Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877396/
https://ncbi.nlm.nih.gov/pubmed/29598822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1125-5
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