Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

BACKGROUND: Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation can cause exaggerated neuroinflammatory responses and trigger progressive neurodegeneration. Dimethyl fumarate (DMF) is a FDA-appro...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Paraiso, Hallel C., Kuo, Ping-Chang, Curfman, Eric T., Moon, Haley J., Sweazey, Robert D., Yen, Jui-Hung, Chang, Fen-Lei, Yu, I-Chen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877396/
https://ncbi.nlm.nih.gov/pubmed/29598822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1125-5
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