Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

BACKGROUND: Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation can cause exaggerated neuroinflammatory responses and trigger progressive neurodegeneration. Dimethyl fumarate (DMF) is a FDA-appro...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Paraiso, Hallel C., Kuo, Ping-Chang, Curfman, Eric T., Moon, Haley J., Sweazey, Robert D., Yen, Jui-Hung, Chang, Fen-Lei, Yu, I-Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877396/
https://ncbi.nlm.nih.gov/pubmed/29598822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1125-5
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