Dimethyl fumarate attenuates reactive microglia and long-term memory deficits following systemic immune challenge

BACKGROUND: Systemic inflammation is associated with increased cognitive decline and risk for Alzheimer’s disease. Microglia (MG) activated during systemic inflammation can cause exaggerated neuroinflammatory responses and trigger progressive neurodegeneration. Dimethyl fumarate (DMF) is a FDA-appro...

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Detalles Bibliográficos
Publicado en:J Neuroinflammation
Main Authors: Paraiso, Hallel C., Kuo, Ping-Chang, Curfman, Eric T., Moon, Haley J., Sweazey, Robert D., Yen, Jui-Hung, Chang, Fen-Lei, Yu, I-Chen
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2018
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877396/
https://ncbi.nlm.nih.gov/pubmed/29598822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1125-5
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