Dimethyl itaconate, an itaconate derivative, exhibits immunomodulatory effects on neuroinflammation in experimental autoimmune encephalomyelitis

BACKGROUND: Inflammatory stimuli induce immunoresponsive gene 1 (IRG1) expression that in turn catalyzes the production of itaconate from the tricarboxylic acid cycle. Itaconate has recently emerged as a regulator of immune cell functions, especially in macrophages. Studies show that itaconate is re...

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Publicado en:J Neuroinflammation
Main Authors: Kuo, Ping-Chang, Weng, Wen-Tsan, Scofield, Barbara A., Paraiso, Hallel C., Brown, Dennis A., Wang, Pei-Yu, Yu, I-Chen, Yen, Jui-Hung
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7191722/
https://ncbi.nlm.nih.gov/pubmed/32349768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01768-7
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