Elevated 20-HETE in Metabolic Syndrome Regulates Arterial Stiffness and Systolic Hypertension via MMP12 Activation

Arterial stiffness plays a causal role in development of systolic hypertension. 20-hydroxyeicosatetraeonic acid (20-HETE), a cytochrome P450 (CYP450)-derived arachidonic acid metabolite, is known to be elevated in resistance arteries in hypertensive animal models and loosely associated with obesity...

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Pubblicato in:J Mol Cell Cardiol
Autori principali: Soler, Amanda, Hunter, Ian, Joseph, Gregory, Hutcheson, Rebecca, Hutcheson, Brenda, Yang, Jenny, Zhang, Frank Fan, Joshi, Sachindra Raj, Bradford, Chastity, Gotlinger, Katherine H., Maniyar, Rachana, Falck, John R., Proctor, Spencer, Schwartzman, Michal Laniado, Gupte, Sachin A., Rocic, Petra
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877315/
https://ncbi.nlm.nih.gov/pubmed/29428638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.005
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