SIRT6 facilitates directional telomere movement upon oxidative damage

Oxidative damage to telomeres leads to telomere attrition and genomic instability, resulting in poor cell viability. Telomere dynamics contribute to the maintenance of telomere integrity; however, whether oxidative damage induces telomere movement and how telomere mobility is regulated remain poorly...

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Udgivet i:Sci Rep
Main Authors: Gao, Ying, Tan, Jun, Jin, Jingyi, Ma, Hongqiang, Chen, Xiukai, Leger, Brittany, Xu, Jianquan, Spagnol, Stephen T., Dahl, Kris Noel, Levine, Arthur S., Liu, Yang, Lan, Li
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876328/
https://ncbi.nlm.nih.gov/pubmed/29599436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23602-0
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