The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

The complement system is essential for host defense, but uncontrolled complement system activation leads to severe, mostly renal pathologies, such as atypical hemolytic uremic syndrome or C3 glomerulopathy. Here, we investigated a novel combinational approach to modulate complement activation by tar...

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Dettagli Bibliografici
Pubblicato in:J Am Soc Nephrol
Autori principali: Michelfelder, Stefan, Fischer, Friedericke, Wäldin, Astrid, Hörle, Kim V., Pohl, Martin, Parsons, Juliana, Reski, Ralf, Decker, Eva L., Zipfel, Peter F., Skerka, Christine, Häffner, Karsten
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Nephrology 2018
Soggetti:
Basic Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875950/
https://ncbi.nlm.nih.gov/pubmed/29335241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017070738
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