Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders

Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement fact...

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Bibliografische gegevens
Gepubliceerd in:J Am Soc Nephrol
Hoofdauteurs: Michelfelder, Stefan, Parsons, Juliana, Bohlender, Lennard L., Hoernstein, Sebastian N.W., Niederkrüger, Holger, Busch, Andreas, Krieghoff, Nicola, Koch, Jonas, Fode, Benjamin, Schaaf, Andreas, Frischmuth, Thomas, Pohl, Martin, Zipfel, Peter F., Reski, Ralf, Decker, Eva L., Häffner, Karsten
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Nephrology 2017
Onderwerpen:
Basic Research
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407710/
https://ncbi.nlm.nih.gov/pubmed/27932477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070745
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