Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders

Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement fact...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Michelfelder, Stefan, Parsons, Juliana, Bohlender, Lennard L., Hoernstein, Sebastian N.W., Niederkrüger, Holger, Busch, Andreas, Krieghoff, Nicola, Koch, Jonas, Fode, Benjamin, Schaaf, Andreas, Frischmuth, Thomas, Pohl, Martin, Zipfel, Peter F., Reski, Ralf, Decker, Eva L., Häffner, Karsten
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2017
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407710/
https://ncbi.nlm.nih.gov/pubmed/27932477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070745
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