Moss-Produced, Glycosylation-Optimized Human Factor H for Therapeutic Application in Complement Disorders

Genetic defects in complement regulatory proteins can lead to severe renal diseases, including atypical hemolytic uremic syndrome and C3 glomerulopathies, and age-related macular degeneration. The majority of the mutations found in patients with these diseases affect the glycoprotein complement fact...

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Bibliografske podrobnosti
izdano v:J Am Soc Nephrol
Main Authors: Michelfelder, Stefan, Parsons, Juliana, Bohlender, Lennard L., Hoernstein, Sebastian N.W., Niederkrüger, Holger, Busch, Andreas, Krieghoff, Nicola, Koch, Jonas, Fode, Benjamin, Schaaf, Andreas, Frischmuth, Thomas, Pohl, Martin, Zipfel, Peter F., Reski, Ralf, Decker, Eva L., Häffner, Karsten
Format: Artigo
Jezik:Inglês
Izdano: American Society of Nephrology 2017
Teme:
Basic Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407710/
https://ncbi.nlm.nih.gov/pubmed/27932477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015070745
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