The MFHR1 Fusion Protein Is a Novel Synthetic Multitarget Complement Inhibitor with Therapeutic Potential

The complement system is essential for host defense, but uncontrolled complement system activation leads to severe, mostly renal pathologies, such as atypical hemolytic uremic syndrome or C3 glomerulopathy. Here, we investigated a novel combinational approach to modulate complement activation by tar...

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Foilsithe in:J Am Soc Nephrol
Main Authors: Michelfelder, Stefan, Fischer, Friedericke, Wäldin, Astrid, Hörle, Kim V., Pohl, Martin, Parsons, Juliana, Reski, Ralf, Decker, Eva L., Zipfel, Peter F., Skerka, Christine, Häffner, Karsten
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Nephrology 2018
Ábhair:
Basic Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5875950/
https://ncbi.nlm.nih.gov/pubmed/29335241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2017070738
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