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The murine β-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes

Locus control regions (LCRs) are defined by their ability to confer high-level tissue-specific expression to linked genes in transgenic assays. Previously, we reported that, at its native site, the murine β-globin LCR is required for high-level β-globin gene expression, but is not required to initia...

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Hlavní autoři: Schübeler, Dirk, Groudine, Mark, Bender, M. A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2001
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC58747/
https://ncbi.nlm.nih.gov/pubmed/11553791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.201394698
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