Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

We have previously reported that the fractalkine (FKN)/CX3CR1 system represents a novel regulatory mechanism for insulin secretion and β cell function. Here, we demonstrate that chronic administration of a long-acting form of FKN, FKN-Fc, can exert durable effects to improve glucose tolerance with i...

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Udgivet i:J Clin Invest
Main Authors: Riopel, Matthew, Seo, Jong Bae, Bandyopadhyay, Gautam K., Li, Pingping, Wollam, Joshua, Chung, Heekyung, Jung, Seung-Ryoung, Murphy, Anne, Wilson, Maria, de Jong, Ron, Patel, Sanjay, Balakrishna, Deepika, Bilakovics, James, Fanjul, Andrea, Plonowski, Artur, Koh, Duk-Su, Larson, Christopher J., Olefsky, Jerrold M., Lee, Yun Sok
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873865/
https://ncbi.nlm.nih.gov/pubmed/29504946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI94330
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