TAZ is a Negative Regulator of PPARγ Activity in Adipocytes and TAZ deletion Improves Insulin Sensitivity and Glucose Tolerance

Insulin resistance is a major factor in obesity-linked type 2 diabetes. PPARγ is a master regulator of adipogenesis and small molecule agonists, termed thiazolidinediones, are potent therapeutic insulin sensitizers. Here, we studied the role of TAZ (Transcriptional Co-Activator with PDZ-binding moti...

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Detalhes bibliográficos
Publicado no:Cell Metab
Main Authors: Ouarrat, Dalila El, Isaac, Roi, Lee, Yun Sok, Oh, Da Young, Wollam, Joshua, Lackey, Denise, Riopel, Matthew, Bandyopadhyay, Gautam, Seo, Jong Bae, Sampath-Kumar, Revathy, Olefsky, Jerrold M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7784082/
https://ncbi.nlm.nih.gov/pubmed/31708444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2019.10.003
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