Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

OBJECTIVE: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...

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Udgivet i:Mol Metab
Main Authors: Mayoral, Rafael, Osborn, Olivia, McNelis, Joanne, Johnson, Andrew M., Oh, Da Young, Izquierdo, Cristina Llorente, Chung, Heekyung, Li, Pingping, Traves, Paqui G., Bandyopadhyay, Gautam, Pessentheiner, Ariane R., Ofrecio, Jachelle M., Cook, Joshua R., Qiang, Li, Accili, Domenico, Olefsky, Jerrold M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421024/
https://ncbi.nlm.nih.gov/pubmed/25973386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.02.007
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