Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

OBJECTIVE: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...

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Vydáno v:Mol Metab
Hlavní autoři: Mayoral, Rafael, Osborn, Olivia, McNelis, Joanne, Johnson, Andrew M., Oh, Da Young, Izquierdo, Cristina Llorente, Chung, Heekyung, Li, Pingping, Traves, Paqui G., Bandyopadhyay, Gautam, Pessentheiner, Ariane R., Ofrecio, Jachelle M., Cook, Joshua R., Qiang, Li, Accili, Domenico, Olefsky, Jerrold M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2015
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421024/
https://ncbi.nlm.nih.gov/pubmed/25973386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.02.007
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