Adipocyte SIRT1 knockout promotes PPARγ activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity

OBJECTIVE: Adipose tissue is the primary site for lipid deposition that protects the organisms in cases of nutrient excess during obesogenic diets. The histone deacetylase Sirtuin 1 (SIRT1) inhibits adipocyte differentiation by targeting the transcription factor peroxisome proliferator activated-rec...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Mayoral, Rafael, Osborn, Olivia, McNelis, Joanne, Johnson, Andrew M., Oh, Da Young, Izquierdo, Cristina Llorente, Chung, Heekyung, Li, Pingping, Traves, Paqui G., Bandyopadhyay, Gautam, Pessentheiner, Ariane R., Ofrecio, Jachelle M., Cook, Joshua R., Qiang, Li, Accili, Domenico, Olefsky, Jerrold M.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4421024/
https://ncbi.nlm.nih.gov/pubmed/25973386
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2015.02.007
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