Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice

Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocyte specific PU.1 knockout mice using adiponectin c...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lackey, Denise E., Reis, Felipe C. G., Isaac, Roi, Zapata, Rizaldy C., El Ouarrat, Dalila, Lee, Yun Sok, Bandyopadhyay, Gautam, Ofrecio, Jachelle M., Oh, Da Young, Osborn, Olivia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791934/
https://ncbi.nlm.nih.gov/pubmed/31611602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51196-8
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