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Adipocyte PU.1 knockout promotes insulin sensitivity in HFD-fed obese mice
Insulin resistance is a key feature of obesity and type 2 diabetes. PU.1 is a master transcription factor predominantly expressed in macrophages but after HFD feeding PU.1 expression is also significantly increased in adipocytes. We generated adipocyte specific PU.1 knockout mice using adiponectin c...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6791934/ https://ncbi.nlm.nih.gov/pubmed/31611602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-51196-8 |
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