CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice

OBJECTIVE: Atherosclerosis is a major cause of cardiovascular disease. Monocyte-endothelial cell interactions are partly mediated by expression of monocyte CX3CR1 and endothelial cell fractalkine (CX3CL1). Interrupting the interaction between this ligand–receptor pair should reduce monocyte binding...

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Publicat a:Mol Metab
Autors principals: Riopel, Matthew, Vassallo, Melanie, Ehinger, Erik, Pattison, Jennifer, Bowden, Karen, Winkels, Holger, Wilson, Maria, de Jong, Ron, Patel, Sanjay, Balakrishna, Deepika, Bilakovics, James, Fanjul, Andrea, Plonowski, Artur, Larson, Christopher J., Ley, Klaus, Cabrales, Pedro, Witztum, Joseph L., Olefsky, Jerrold M., Lee, Yun Sok
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2018
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6358552/
https://ncbi.nlm.nih.gov/pubmed/30553772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.11.011
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