ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line

Excess production of reactive oxygen species (ROS) is known to cause apoptotic cell death. However, the molecular mechanisms whereby ROS induce apoptosis remain elusive. Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-indu...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Nishi, Kensuke, Iwaihara, Yuri, Tsunoda, Toshiyuki, Doi, Keiko, Sakata, Toshifumi, Shirasawa, Senji, Ishikura, Shuhei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870588/
https://ncbi.nlm.nih.gov/pubmed/29242562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0006-7
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