Zfat-Deficiency Results in a Loss of CD3ζ Phosphorylation with Dysregulation of ERK and Egr Activities Leading to Impaired Positive Selection

The human ZFAT gene was originally identified as a susceptibility gene for autoimmune thyroid disease. Mouse Zfat is a critical transcriptional regulator for primitive hematopoiesis and required for peripheral T cell homeostasis. However, its physiological roles in T cell development remain poorly u...

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Detalhes bibliográficos
Main Authors: Ogawa, Masahiro, Okamura, Tadashi, Ishikura, Shuhei, Doi, Keiko, Matsuzaki, Hiroshi, Tanaka, Yoko, Ota, Takeharu, Hayakawa, Kunihiro, Suzuki, Harumi, Tsunoda, Toshiyuki, Sasazuki, Takehiko, Shirasawa, Senji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789737/
https://ncbi.nlm.nih.gov/pubmed/24098453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076254
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