ROS-induced cleavage of NHLRC2 by caspase-8 leads to apoptotic cell death in the HCT116 human colon cancer cell line

Excess production of reactive oxygen species (ROS) is known to cause apoptotic cell death. However, the molecular mechanisms whereby ROS induce apoptosis remain elusive. Here we show that the NHL-repeat-containing protein 2 (NHLRC2) thioredoxin-like domain protein is cleaved by caspase-8 in ROS-indu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Nishi, Kensuke, Iwaihara, Yuri, Tsunoda, Toshiyuki, Doi, Keiko, Sakata, Toshifumi, Shirasawa, Senji, Ishikura, Shuhei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5870588/
https://ncbi.nlm.nih.gov/pubmed/29242562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0006-7
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