Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice

In the adult mammalian hippocampus, new neurons are constantly added to the dentate gyrus. Adult neurogenesis is impaired in several neurodegenerative mouse models including α-synuclein (a-syn) transgenic mice. Among different a-syn species, a-syn oligomers were reported to be the most toxic species...

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Библиографические подробности
Опубликовано в: :Brain Struct Funct
Главные авторы: Regensburger, Martin, Schreglmann, Sebastian R., Stoll, Svenja, Rockenstein, Edward, Loskarn, Sandra, Xiang, Wei, Masliah, Eliezer, Winner, Beate
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2017
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5869938/
https://ncbi.nlm.nih.gov/pubmed/29124353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00429-017-1561-5
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