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Inflammatory Immune Cells May Impair the PreBCR Checkpoint, Reduce New B Cell Production, and Alter the Antibody Repertoire in Old Age()
Aging impairs development of new B cells and diminishes the expression of protective antibodies. Reduced numbers of B cell precursors generally occur in old (~2 yrs.) mice. At the pro-B to pre-B cell transition, the pre-B cell receptor (preBCR) checkpoint directs pre-B cell expansion and selection o...
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| Publicado no: | Exp Gerontol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5869160/ https://ncbi.nlm.nih.gov/pubmed/29408522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exger.2018.01.023 |
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