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In Old BALB/c Mice, Bone Marrow Pre-B Cell and Surrogate Light Chain Reduction Is Associated With Increased B Cell Reactivity to Phosphorylcholine, But Reduced T15 Idiotype Dominance
In young adult BALB/c mice, antibodies to phosphorylcholine (PC) bearing the T15 (TEPC 15) idiotype confer protection against pneumococcal infections. In old age, even though PC reactive B cells are often increased, the proportion of T15(+) antibodies declines. We hypothesize that limited surrogate...
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| Publicado no: | Mech Ageing Dev |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5381390/ https://ncbi.nlm.nih.gov/pubmed/27876385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2016.11.004 |
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