In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells

In aged mice, new B-cell development is diminished and the antibody repertoire becomes more autoreactive. Our studies suggest that (i) apoptosis contributes to reduced B lymphopoiesis in old age and preferentially eliminates those B-cell precursors with higher levels of the surrogate light chain (SL...

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Detalhes bibliográficos
Publicado no:Aging Cell
Main Authors: Ratliff, Michelle, Alter, Sarah, McAvoy, Kelly, Frasca, Daniela, Wright, Jacqueline A, Zinkel, Sandra S, Khan, Wasif N, Blomberg, Bonnie B, Riley, Richard L
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406667/
https://ncbi.nlm.nih.gov/pubmed/25727904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12302
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