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In Senescence, Age-associated B Cells (ABC) Secrete TNFα and Inhibit Survival of B Cell Precursors()
Aged mice exhibit ~ 5-10 fold increases in an ordinarily minor CD21/35(−) CD23(−) mature B cell subset termed age-associated B cells (ABC). ABC from old, but not young, mice induce apoptosis in pro-B cells directly through secretion of TNFα. In addition, aged ABC, via TNFα, stimulate bone marrow cel...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3716274/ https://ncbi.nlm.nih.gov/pubmed/23410004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12055 |
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