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E47 retroviral rescue of intrinsic B-cell defects in senescent mice
In aging, immune responses are dramatically impaired, specifically the ability to produce protective antibodies. We previously showed that with age there is a B-cell intrinsic decrease in class switch recombination (CSR) because of a decrease in activation-induced cytidine deaminase (AID). One mecha...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4710514/ https://ncbi.nlm.nih.gov/pubmed/21241451 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2011.00673.x |
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