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A molecular mechanism for TNF-α-mediated down-regulation of B cell responses()
B cell function with age is decreased in class switch recombination (CSR), activation-induced cytidine deaminase (AID) and stability of E47 mRNA. The latter is regulated at least in part by tristetraprolin (TTP) which is increased in aged B cells and also negatively regulates TNF-α. Here, we investi...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3700394/ https://ncbi.nlm.nih.gov/pubmed/22116831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003964 |
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