Deviation of the B Cell Pathway in Senescent Mice is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression

Liknande verk

• Old Mice Retain Bone Marrow B1 Progenitors, but Lose B2 Precursors, and Exhibit Altered Immature B Cell Phenotype and Light Chain Usage
  av: Alter-Wolf, Sarah, et al.
  Publicerad: (2009)
• NK Cells in the CD19(-) B220(+) Bone Marrow Fraction are Increased in Senescence and Reduce E2A and Surrogate Light Chain Proteins in B Cell Precursors
  av: King, Anne M., et al.
  Publicerad: (2009)
• In Old BALB/c Mice, Bone Marrow Pre-B Cell and Surrogate Light Chain Reduction Is Associated With Increased B Cell Reactivity to Phosphorylcholine, But Reduced T15 Idiotype Dominance
  av: Khomtchouk, Kelly, et al.
  Publicerad: (2016)
• In aged mice, low surrogate light chain promotes pro-B-cell apoptotic resistance, compromises the PreBCR checkpoint, and favors generation of autoreactive, phosphorylcholine-specific B cells
  av: Ratliff, Michelle, et al.
  Publicerad: (2015)
• In Senescence, Age-associated B Cells (ABC) Secrete TNFα and Inhibit Survival of B Cell Precursors()
  av: Ratliff, Michelle, et al.
  Publicerad: (2013)