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Deviation of the B Cell Pathway in Senescent Mice is Associated with Reduced Surrogate Light Chain Expression and Altered Immature B Cell Generation, Phenotype, and Light Chain Expression
B lymphopoiesis in aged mice is characterized by reduced B cell precursors and an altered antibody repertoire. This likely results, in part, from reduced surrogate light chains in senescent B cell precursors and compromised preBCR checkpoints. Herein, we show that aged mice maintain an ordinarily mi...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749601/ https://ncbi.nlm.nih.gov/pubmed/19109144 |
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