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Old Mice Retain Bone Marrow B1 Progenitors, but Lose B2 Precursors, and Exhibit Altered Immature B Cell Phenotype and Light Chain Usage
The bone marrow of old adult mice (∼2 yrs. old) have reduced B lymphopoiesis; however, whether the B1 pathway in adult bone marrow is also compromised in senescence is not known. Herein, we show that phenotypic (IgM(-)Lin(-)CD93(+)[AA4.1(+)] CD19(+)B220(low/-)) B1 progenitors are retained in old bon...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734388/ https://ncbi.nlm.nih.gov/pubmed/19428460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2009.04.001 |
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