Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine

The natural alkaloid berberine has been ascribed numerous health benefits including lipid and cholesterol reduction and improved insulin sensitivity in diabetics. However, oral (PO) administration of berberine is hindered by poor bioavailability and increasing dose often elicits gastro-intestinal si...

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Bibliographic Details
Published in:PLoS One
Main Authors: Buchanan, Beth, Meng, Qingfang, Poulin, Mathieu-Marc, Zuccolo, Jonathan, Azike, Chike Godwin, Gabriele, Joseph, Baranowski, David Charles
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5868852/
https://ncbi.nlm.nih.gov/pubmed/29579096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0194979
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